Featured Pubs

PUBLICATION LIST

Pre-Prints:

Nicholas Pervolarakis, Quy H. Nguyen, Guadalupe Gutierrez, Peng Sun, Darisha Jhutty, Grace XY Zheng, Corey M Nemec, Xing Dai, Kazuhide Watanabe and Kai Kessenbrock. Integrated single-cell transcriptomics and chromatin accessibility analysis reveals novel regulators of mammary epithelial cell identity. bioRxiv . doi: https://doi.org/10.1101/740746

Hamad Alshetaiwi, Nicholas Pervolarakis, Laura Lynn McIntyre, Dennis Ma, Quy H. Nguyen, Jan Akara Rath, Kevin Nee, Grace Hernandez, Katrina Evans, Leona Torosian, Anushka Silva, Craig Walsh, Kai Kessenbrock. Defining the emergence of myeloid-derived suppressor cells in breast cancer using single-cell transcriptomics. bioRxiv 702860; doi: https://doi.org/10.1101/702860

Daniel William Haensel, Suoqin Jin, Rachel Cinco, Peng Sun, Quy Nguyen, Zixuan Cang, Morgan Dragan, Yanwen Gong, Adam L MacLean, Kai Kessenbrock, Enrico Gratton, Qing Nie, Xing Dai. Defining epidermal basal cell states during skin homeostasis and wound healing using single-cell transcriptomics.

Peer-Reviewed:

2019

Samocha A, Doh H, Kessenbrock K and Roose JP. Unraveling Heterogeneity in Epithelial Cell Fates of the Mammary Gland and Breast Cancer. Cancers 2019, 11(10), 1423; https://doi.org/10.3390/cancers11101423

Chen W, Morabito S, Kessenbrock K, Enver T, Meyer KB, Teschendorff AE. Single-cell landscape in mammary epithelium reveals bipotent-like cells associated with breast cancer risk and outcome. Communications Biology. volume 2, Article number: 306 (2019). https://www.nature.com/articles/s42003-019-0554-8

Guerrero-Juarez CF, Dedhia PH, Jin S, Ruiz-Vega R, Ma D, Liu Y, Yamaga K, Shestova O, Gay DL, Yang Z, Kessenbrock K, Nie Q, Pear WS, Cotsarelis G, Plikus MV. Single-cell analysis reveals fibroblast heterogeneity and myeloid-derived adipocyte progenitors in murine skin wounds. Nature Communications. 2019 Feb 8;10(1):650. doi: 10.1038/s41467-018-08247-x.

2018

Lawson DA#, Kessenbrock K#, Davis RT, Pervolarakis N, Werb Z. Tumour Heterogeneity and metastasis in single-cell resolution. Nature Cell Biology. 2018 20, 1349-1360. https://www.nature.com/articles/s41556-018-0236-7 #corresponding author

Nguyen QH*, Pervolarakis N*, Blake K, Ma D, Davis RT, James J, Phung AT, Willey E, Kumar R, Jabart E, Driver I, Rock J, Goga A, Khan SA, Lawson DA, Werb Z#, Kessenbrock K#. Profiling human breast epithelial cells using single cell RNA sequencing reveals spectrum of cell diversity. Nature Communications  2018 May 23;9(1):2028. https://rdcu.be/OZmF #corresponding author; *Co-first author

Nguyen QH, Pervolarakis N, Nee K, Kessenbrock K#. Experimental considerations for single cell RNA sequencing approaches. Front. Cell. Dev. Biol. 2018 Sep 4;6:108. https://doi.org/10.3389/fcell.2018.00108 #corresponding author

Qiu X, Lombardo JA , Westerhof TM , Pennell M , Ng A , Alshetaiwi H , Luna BM , Nelson EL , Kessenbrock K , Hui EE , Haun JB .Microfluidic filter device with nylon mesh membranes efficiently dissociates cell aggregates and digested tissue into single cells. Lab Chip. 2018 18:2776-2786. doi:10.1039/c8lc00507a.

Takai K, Drain AP, Lawson DA, Littlepage LE, Karpuj M, Kessenbrock K, Le A, Inoue K, Weaver VM and Werb Z. Discoidin domain receptor 1 (DDR1) ablation promotes tissue fibrosis and hypoxia to induce aggressive, basal-like breast cancers. Genes & Dev. (2018).

2017

Kessenbrock K*, Smith P*, Steenbeek S, Pervolarakis N, Kumar R, Minami Y, Goga A, Hinck L, Werb Z. Diverse regulation of mammary epithelial growth and branching morphogenesis through non-canonical Wnt signaling. Proc. Natl. Acad. Sci. 2017. 114(12):3121-3126        *contributed equally

2016

Horiuchi D, Zhou AY, Corella AN, Yau C, Balakrishnan S, Kessenbrock K, Lawson DA, Anderton BN, Bazarov AV, Eyob H, Yaswen P, McManus MT, Rugo HS, Werb Z, Goga A. PIM kinase inhibition presents a novel targeted therapy against triple-negative breast tumors with elevated MYC expression. Nat Med. 2016 Nov;22(11):1321-1329. doi: 10.1038/nm.4213.

Park J, Wysocki RW, Amoozgar Z, Maiorino L, Fein MR, Jorns J, Schott AF, Kinugasa-Katayama Y, Lee Y, Won NH, Nakasone ES, Hearn SA, Küttner V, Qiu J, Almeida AS, Perurena N, Kessenbrock K, Goldberg MS, Egeblad M. Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps. Science Translational Medicine. 2016 Oct 19;8(361):361ra138.

Selected Publications from before Lab Start in 2016

Lawson D.A., Bhakta N., Kessenbrock K., Prummel K., Yu Y., Takai K., Yaswen P., Welm A., Goga A., Werb Z., Single-cell analysis reveals a stem cell transcription program in human metastatic breast cancer cells. Nature. 2015 526:131-5

Kessenbrock K.*, Dijkgraaf G.J.*, Lawson D.A., Littlepage L.E., Shahi P., Pieper U., Werb Z. A role for matrix metalloproteinases in the regulation of mammary stem cells via the Wnt signaling pathway. Cell Stem Cell. 2013; 13:300-13; *equal contribution

Caudrillier A., Kessenbrock K., Gilliss, B.M., Ngyen J.X., Marques M.B., Monestier M., Toy P., Werb Z., Looney M.R., Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury. J Clin Invest. 2012; 122:2661-71.

Kessenbrock K., Plaks V., Werb Z., Matrix Metalloproteinases: Regulators of the Tumor Microenvironment. Cell. 2010; 141:52-67. Review

Kessenbrock K.#, Krumbholz M., Schoenermarck U., Back W., Gross W.L., Werb Z., Groene H.J., Brinkmann V., Jenne D.E. #, Netting neutrophils in autoimmune small-vessel vasculitis. Nat Med. 2009; 15:623-625. #corresponding author

Kessenbrock K.#, Fröhlich L., Sixt M., Lämmermann T., Bateman A., Belaaouaj A., Ring J., Ollerrt M., Fässler R., Jenne D.E. #, Proteinase 3 and neutrophil elastase enhance inflammation by inactivating anti-inflammatory progranulin. J Clin Invest. 2008; 118:2438-2447. #corresponding author

Riedl J.*, Crevenna A.H.*, Kessenbrock K., Yu J.H., Neukirchen D., Bista M., Bradke F., Jenne D.E., Holak T.A., Werb Z., Sixt M., Wedlich-Soldner R., Lifeact – a novel versatile marker for the visualization of F-actin. Nat Meth. 2008; 5:605-607. *equal contribution

Kessenbrock K., Fritzler M.J., Groves M., Eissfeller P., von Mühlen C.A., Höpfl P., Mahler M., Diverse humoral autoimmunity to the ribosomal P proteins in systemic lupus erythematosus and hepatitis C virus infection. J Mol Med. 2007 85:953-959.

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