Featured Pubs
PUBLICATION LIST
GOOGLE SCHOLAR: LINK
Peer-Reviewed:
2020
Pervolarakis N, Nguyen QH, Williams J, Gong Y, Gutierrez G, Sun P, Jhutty D, Zheng GX, Nemec CM, Dai X, Watanabe K#, Kessenbrock K#. Integrated single-cell transcriptomics and chromatin accessibility analysis reveals novel regulators of mammary epithelial cell identity. Cell Reports. 2020 Oct 20; 33(3):108273. LINK
Alshetaiwi H, Pervolarakis N, McIntyre LL, Ma D, Nguyen QH, Rath JA, Nee K, Hernandez G, Evans K, Torosian L, Silva A, Walsh C, Kessenbrock K. Defining the emergence of myeloid-derived suppressor cells in breast cancer using single-cell transcriptomics. Science Immunology. 2020 Feb 21;5(44). pii: eaay6017. doi: 10.1126/sciimmunol.aay6017
Defining epidermal basal cell states during skin homeostasis and wound healing using single-cell transcriptomics.
Sun P, Dragan M, Vu R, Haensel D, Gutierrez G, Nguyen QH, Ma X, Huang DH, Watanabe K, Greenberg E, Wu J, Atwood S, Pearlman E, Han W, Kessenbrock K, and Dai X. Epidermis-intrinsic transcriptional mechanism coordinates barrier maintenance and neutrophil accumulation during skin inflammation. The Journal of Investigative Dermatology. In press
2019
Samocha A, Doh H, Kessenbrock K and Roose JP. Unraveling Heterogeneity in Epithelial Cell Fates of the Mammary Gland and Breast Cancer. Cancers 2019, 11(10), 1423; https://doi.org/10.3390/cancers11101423
Chen W, Morabito S, Kessenbrock K, Enver T, Meyer KB, Teschendorff AE. Single-cell landscape in mammary epithelium reveals bipotent-like cells associated with breast cancer risk and outcome. Communications Biology. volume 2, Article number: 306 (2019). https://www.nature.com/articles/s42003-019-0554-8
Guerrero-Juarez CF, Dedhia PH, Jin S, Ruiz-Vega R, Ma D, Liu Y, Yamaga K, Shestova O, Gay DL, Yang Z, Kessenbrock K, Nie Q, Pear WS, Cotsarelis G, Plikus MV. Single-cell analysis reveals fibroblast heterogeneity and myeloid-derived adipocyte progenitors in murine skin wounds. Nature Communications. 2019 Feb 8;10(1):650. doi: 10.1038/s41467-018-08247-x.
2018
Lawson DA#, Kessenbrock K#, Davis RT, Pervolarakis N, Werb Z. Tumour Heterogeneity and metastasis in single-cell resolution. Nature Cell Biology. 2018 20, 1349-1360. https://www.nature.com/articles/s41556-018-0236-7 #corresponding author
Nguyen QH*, Pervolarakis N*, Blake K, Ma D, Davis RT, James J, Phung AT, Willey E, Kumar R, Jabart E, Driver I, Rock J, Goga A, Khan SA, Lawson DA, Werb Z#, Kessenbrock K#. Profiling human breast epithelial cells using single cell RNA sequencing reveals spectrum of cell diversity. Nature Communications 2018 May 23;9(1):2028. https://rdcu.be/OZmF #corresponding author; *Co-first author
Nguyen QH, Pervolarakis N, Nee K, Kessenbrock K#. Experimental considerations for single cell RNA sequencing approaches. Front. Cell. Dev. Biol. 2018 Sep 4;6:108. https://doi.org/10.3389/fcell.2018.00108 #corresponding author
Qiu X, Lombardo JA , Westerhof TM , Pennell M , Ng A , Alshetaiwi H , Luna BM , Nelson EL , Kessenbrock K , Hui EE , Haun JB .Microfluidic filter device with nylon mesh membranes efficiently dissociates cell aggregates and digested tissue into single cells. Lab Chip. 2018 18:2776-2786. doi:10.1039/c8lc00507a.
Takai K, Drain AP, Lawson DA, Littlepage LE, Karpuj M, Kessenbrock K, Le A, Inoue K, Weaver VM and Werb Z. Discoidin domain receptor 1 (DDR1) ablation promotes tissue fibrosis and hypoxia to induce aggressive, basal-like breast cancers. Genes & Dev. (2018).
2017
Kessenbrock K*, Smith P*, Steenbeek S, Pervolarakis N, Kumar R, Minami Y, Goga A, Hinck L, Werb Z. Diverse regulation of mammary epithelial growth and branching morphogenesis through non-canonical Wnt signaling. Proc. Natl. Acad. Sci. 2017. 114(12):3121-3126 *contributed equally
2016
Horiuchi D, Zhou AY, Corella AN, Yau C, Balakrishnan S, Kessenbrock K, Lawson DA, Anderton BN, Bazarov AV, Eyob H, Yaswen P, McManus MT, Rugo HS, Werb Z, Goga A. PIM kinase inhibition presents a novel targeted therapy against triple-negative breast tumors with elevated MYC expression. Nat Med. 2016 Nov;22(11):1321-1329. doi: 10.1038/nm.4213.
Park J, Wysocki RW, Amoozgar Z, Maiorino L, Fein MR, Jorns J, Schott AF, Kinugasa-Katayama Y, Lee Y, Won NH, Nakasone ES, Hearn SA, Küttner V, Qiu J, Almeida AS, Perurena N, Kessenbrock K, Goldberg MS, Egeblad M. Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps. Science Translational Medicine. 2016 Oct 19;8(361):361ra138.
Selected Publications from before Lab Start in 2016
Lawson D.A., Bhakta N., Kessenbrock K., Prummel K., Yu Y., Takai K., Yaswen P., Welm A., Goga A., Werb Z., Single-cell analysis reveals a stem cell transcription program in human metastatic breast cancer cells. Nature. 2015 526:131-5
Kessenbrock K.*, Dijkgraaf G.J.*, Lawson D.A., Littlepage L.E., Shahi P., Pieper U., Werb Z. A role for matrix metalloproteinases in the regulation of mammary stem cells via the Wnt signaling pathway. Cell Stem Cell. 2013; 13:300-13; *equal contribution
Caudrillier A., Kessenbrock K., Gilliss, B.M., Ngyen J.X., Marques M.B., Monestier M., Toy P., Werb Z., Looney M.R., Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury. J Clin Invest. 2012; 122:2661-71.
Kessenbrock K., Plaks V., Werb Z., Matrix Metalloproteinases: Regulators of the Tumor Microenvironment. Cell. 2010; 141:52-67. Review
Kessenbrock K.#, Krumbholz M., Schoenermarck U., Back W., Gross W.L., Werb Z., Groene H.J., Brinkmann V., Jenne D.E. #, Netting neutrophils in autoimmune small-vessel vasculitis. Nat Med. 2009; 15:623-625. #corresponding author
Kessenbrock K.#, Fröhlich L., Sixt M., Lämmermann T., Bateman A., Belaaouaj A., Ring J., Ollerrt M., Fässler R., Jenne D.E. #, Proteinase 3 and neutrophil elastase enhance inflammation by inactivating anti-inflammatory progranulin. J Clin Invest. 2008; 118:2438-2447. #corresponding author
Riedl J.*, Crevenna A.H.*, Kessenbrock K., Yu J.H., Neukirchen D., Bista M., Bradke F., Jenne D.E., Holak T.A., Werb Z., Sixt M., Wedlich-Soldner R., Lifeact – a novel versatile marker for the visualization of F-actin. Nat Meth. 2008; 5:605-607. *equal contribution
Kessenbrock K., Fritzler M.J., Groves M., Eissfeller P., von Mühlen C.A., Höpfl P., Mahler M., Diverse humoral autoimmunity to the ribosomal P proteins in systemic lupus erythematosus and hepatitis C virus infection. J Mol Med. 2007 85:953-959.