Featured Pubs

PUBLICATION LIST

Pre-Prints:

Hamad Alshetaiwi, Nicholas Pervolarakis, Laura Lynn McIntyre, Dennis Ma, Quy Nguyen, Jan Akara Rath, Kevin Nee, Grace Hernandez, Katrina Evans, Leona Torosian, Anushka Silva, Craig Walsh, Kai Kessenbrock. Defining the emergence of myeloid-derived suppressor cells in breast cancer using single-cell transcriptomics. bioRxiv 702860; doi: https://doi.org/10.1101/702860

Peer-Reviewed:
2019

Chen W, Morabito S, Kessenbrock K, Enver T, Meyer KB, Teschendorff AE. Single-cell landscape in mammary epithelium reveals bipotent-like cells associated with breast cancer risk and outcome. Communications Biology. volume 2, Article number: 306 (2019). https://www.nature.com/articles/s42003-019-0554-8

Guerrero-Juarez CF, Dedhia PH, Jin S, Ruiz-Vega R, Ma D, Liu Y, Yamaga K, Shestova O, Gay DL, Yang Z, Kessenbrock K, Nie Q, Pear WS, Cotsarelis G, Plikus MV. Single-cell analysis reveals fibroblast heterogeneity and myeloid-derived adipocyte progenitors in murine skin wounds. Nature Communications. 2019 Feb 8;10(1):650. doi: 10.1038/s41467-018-08247-x.

2018

Lawson DA#, Kessenbrock K#, Davis RT, Pervolarakis N, Werb Z. Tumour Heterogeneity and metastasis in single-cell resolution. Nature Cell Biology. 2018 20, 1349-1360. #corresponding author

Nguyen QH*, Pervolarakis N*, Blake K, Ma D, Davis RT, James J, Phung AT, Willey E, Kumar R, Jabart E, Driver I, Rock J, Goga A, Khan SA, Lawson DA, Werb Z#, Kessenbrock K#. Profiling human breast epithelial cells using single cell RNA sequencing reveals spectrum of cell diversity. Nature Communications  2018 May 23;9(1):2028. https://rdcu.be/OZmF #corresponding author; *Co-first author

Nguyen QH, Pervolarakis N, Nee K, Kessenbrock K#. Experimental considerations for single cell RNA sequencing approaches. Front. Cell. Dev. Biol. (in press) #corresponding author

Qiu X, Lombardo JA , Westerhof TM , Pennell M , Ng A , Alshetaiwi H , Luna BM , Nelson EL , Kessenbrock K , Hui EE , Haun JB .Microfluidic filter device with nylon mesh membranes efficiently dissociates cell aggregates and digested tissue into single cells. Lab Chip. 2018 18:2776-2786. doi:10.1039/c8lc00507a.

Takai K, Drain AP, Lawson DA, Littlepage LE, Karpuj M, Kessenbrock K, Le A, Inoue K, Weaver VM and Werb Z. Discoidin domain receptor 1 (DDR1) ablation promotes tissue fibrosis and hypoxia to induce aggressive, basal-like breast cancers. Genes & Dev. In press (2018).

2017

Kessenbrock K*, Smith P*, Steenbeek S, Pervolarakis N, Kumar R, Minami Y, Goga A, Hinck L, Werb Z. Diverse regulation of mammary epithelial growth and branching morphogenesis through non-canonical Wnt signaling. Proc. Natl. Acad. Sci. 2017. 114(12):3121-3126        *contributed equally

2016

Horiuchi D, Zhou AY, Corella AN, Yau C, Balakrishnan S, Kessenbrock K, Lawson DA, Anderton BN, Bazarov AV, Eyob H, Yaswen P, McManus MT, Rugo HS, Werb Z, Goga A. PIM kinase inhibition presents a novel targeted therapy against triple-negative breast tumors with elevated MYC expression. Nature Medicine. 2016 Nov;22(11):1321-1329. doi: 10.1038/nm.4213.

Park J, Wysocki RW, Amoozgar Z, Maiorino L, Fein MR, Jorns J, Schott AF, Kinugasa-Katayama Y, Lee Y, Won NH, Nakasone ES, Hearn SA, Küttner V, Qiu J, Almeida AS, Perurena N, Kessenbrock K, Goldberg MS, Egeblad M. Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps. Science Translational Medicine. 2016 Oct 19;8(361):361ra138.

2015

Lawson D.A., Bhakta N., Kessenbrock K., Prummel K., Yu Y., Takai K., Yaswen P., Welm A., Goga A., Werb Z., Single-cell analysis reveals a stem cell transcription program in human metastatic breast cancer cells. Nature. 2015 526:131-5

Kessenbrock K., Wang C.Y., Werb Z. Matrix metalloproteinases in stem cell regulation and cancer. Matrix Biol. 2015. 44:184-190.

2013

Kessenbrock K.*, Dijkgraaf G.J.*, Lawson D.A., Littlepage L.E., Shahi P., Pieper U., Werb Z. A role for matrix metalloproteinases in the regulation of mammary stem cells via the Wnt signaling pathway. Cell Stem Cell. 2013; 13:300-13; *equal contribution
Featured in: “Preview” Cell Stem Cell. 2013; 13:300; “Research Highlights” Nat Cell Biol. 2013; 15:1033.

2012

Caudrillier A., Kessenbrock K., Gilliss, B.M., Ngyen J.X., Marques M.B., Monestier M., Toy P., Werb Z., Looney M.R., Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury. J Clin Invest. 2012; 122:2661-71. (>100 Citations)
Featured in: http://www.nhlbi.nih.gov/news/spotlight/fact-sheet/nhlbi-top-research-findings-in-fiscal-year-2012.html

2011

Kessenbrock K., Brown M., Werb Z., Measuring matrix metalloproteinase activity in macrophages and polymorphonuclear leukocytes. Curr Protoc Immunol. 2011 Chapter 14:Unit14.24. Review

2010

Kessenbrock K., Plaks V., Werb Z., Matrix Metalloproteinases: Regulators of the Tumor Microenvironment. Cell. 2010; 141:52-67. Review (>1,200 Citations)

Kessenbrock K., Dau T., Jenne D.E., Tailor-made inflammation: how neutrophil serine proteases modulate the inflammatory response. J Mol Med. 2010; 89:23-28. (>30 Citations)

2009

Kessenbrock K.#, Krumbholz M., Schoenermarck U., Back W., Gross W.L., Werb Z., Groene H.J., Brinkmann V., Jenne D.E. #, Netting neutrophils in autoimmune small-vessel vasculitis. Nat Med. 2009; 15:623-625. #corresponding author (>350 Citations)
Featured in: “Editor’s Choice” Science. 2009; 324:1242; “Research Highlights” Nat Rev Rheum. 2009; 5:413

2008

Kessenbrock K.#, Fröhlich L., Sixt M., Lämmermann T., Bateman A., Belaaouaj A., Ring J., Ollerrt M., Fässler R., Jenne D.E. #, Proteinase 3 and neutrophil elastase enhance inflammation by inactivating anti-inflammatory progranulin. J Clin Invest. 2008; 118:2438-2447. #corresponding author (>150 Citations)
Featured in: “In this issue” J Clin Invest. 2008; 118:2367; “Research highlights” Nat Rev Immunol. 2008; 8:572

Riedl J.*, Crevenna A.H.*, Kessenbrock K., Yu J.H., Neukirchen D., Bista M., Bradke F., Jenne D.E., Holak T.A., Werb Z., Sixt M., Wedlich-Soldner R., Lifeact – a novel versatile marker for the visualization of F-actin. Nat Meth. 2008; 5:605-607. *equal contribution (>580 Citations)

2007

Kessenbrock K., Fritzler M.J., Groves M., Eissfeller P., von Mühlen C.A., Höpfl P., Mahler M., Diverse humoral autoimmunity to the ribosomal P proteins in systemic lupus erythematosus and hepatitis C virus infection. J Mol Med. 2007 85:953-959.

Kessenbrock K., Raijmakers R., Fritzler M.J., Mahler M., Synthetic peptides: The future of patient management in systemic rheumatic diseases? Curr Med Chem. 2007; 14:2831-2838.

2004

Mahler M., Kessenbrock K., et al. International multicenter evaluation of autoantibodies to ribosomal P proteins. Clin Vaccine Immunol. 2004; 13:77-83.

Mahler M., Kessenbrock K., Raats J., Fritzler M.J., Technical and clinical evaluation of anti-ribosomal P protein immunoassays. J Clin Lab Anal. 2004; 18:215-23.

2003

Mahler M., Kessenbrock K., Raats J., Williams R., Fritzler M.J., Bluthner M., Characterization of the human autoimmune response to the major C-terminal epitope of the ribosomal P proteins. J Mol Med. 2003 81:194-204.

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