PUBLICATION LIST

GOOGLE SCHOLAR: LINK

Selected Peer-Reviewed:

2024

Fortin BM, Pfeiffer SM, Insua-Rodríguez J, Alshetaiwi H, Moshensky A, Song WA, Mahieu AL, Chun SK, Lewis AN, Hsu A, Adam I, Eng OS, Pannunzio NR, Seldin MM, Marazzi I, Marangoni F, Lawson DA, Kessenbrock K, Masri S. Circadian control of tumor immunosuppression affects efficacy of immune checkpoint blockade. Nature Immunology. 2024 Jul;25(7):1257-1269. LINK: https://www.nature.com/articles/s41590-024-01859-0

Coulis G, Jaime D, Guerrero-Juarez C, Kastenschmidt JM, Farahat PK, Nguyen Q, Pervolarakis N, McLinden K, Thurlow L, Movahedi S, Hughes BS, Duarte J, Sorn A, Montoya E, Mozaffar I, Dragan M, Othy S, Joshi T, Hans CP, Kimonis V, MacLean AL, Nie Q, Wallace LM, Harper SQ, Mozaffar T, Hogarth MW, Bhattacharya S, Jaiswal JK, Golann DR, Su Q, Kessenbrock K, Stec M, Spencer MJ, Zamudio JR, Villalta SA. Single-cell and spatial transcriptomics identify a macrophage population associated with skeletal muscle fibrosis. Science Advances. 2023 Jul 7;9(27)

LINK

2023

Nee K, Ma D, Nguyen QH, Pein M, Gong Y, Jin S, Hernandez G, Pervolarakis N, Alshetawi H, Rauf M, Dave KR, Boyapati K, Calderon C, Markaryan A, Edwards R, Lin E, Parajuli R, Nie Q, LaBarge M, Kessenbrock K^#. Preneoplastic stromal cells drive BRCA1-mediated breast tumorigenesis. Nature Genetics. 2023. PMID: 36914836. ^#corresponding author LINK: https://www.nature.com/articles/s41588-023-01298-x

Kumar T, Nee K, Wei R, He S, Nguyen QH, Bai S, Blake K, Pein M, Gong Y, Sei E, Hu M, Casasent AK, Thennavan A, Li J, Tran T, Chen K, Nilges B, Kashikar N, Braubach O, Ben Cheikh B, Nikulina N, Chen H, Teshome M, Menegaz B, Javaid H, Nagi C, Montalvan J, Lev T, Mallya S, Tifrea DF, Edwards R, Lin E, Parajuli R, Hanson S, Winocour S, Thompson A, Lim B,, Lawson DA^#, Kessenbrock K^#, Navin N^#. A spatially resolved single cell genomic atlas of the adult human breast. Nature. 2023. PMID: 37380767. ^#corresponding author

2022

Yanwen Gong, Shushrruth Sai Srinivasan, Ruiyi Zhang, Kai Kessenbrock^#, Jing Zhang^#. scEpiLock: A Weakly Supervised Learning Framework for cis-Regulatory Element Localization and Variant Impact Quantification for Single-Cell Epigenetic Data. Biomolecules. 2022 Jun 23;12(7):874. ^#corresponding author

2021

Sundus F Shalabi, Masaru Miyano, Rosalyn W Sayaman, Jennifer C Lopez, Tiina A Jokela, Michael E Todhunter, Stefan Hinz, James C Garbe, Martha R Stampfer, Kai Kessenbrock, Victoria E Seewaldt, Mark A LaBarge. Evidence for accelerated aging in mammary epithelia of women carrying germline BRCA1 or BRCA2 mutations. Nat Aging. 2021 Sep;1(9):838-849.

Austin E Y T Lefebvre, Dennis Ma, Kai Kessenbrock, Devon A Lawson, Michelle A Digman. Automated segmentation and tracking of mitochondria in live-cell time-lapse images. Nat Methods. 2021 Sep;18(9):1091-1102.

Alshetaiwi H, Pervolarakis N, Nguyen QH, Kessenbrock K^#. Single cell transcriptome analysis workflow for splenic MDSCs from murine breast cancer models. Methods in Molecular Biology. 2021. 2021;2236:177-187. ^#corresponding author

2020

Pervolarakis N, Nguyen QH, Williams J, Gong Y, Gutierrez G, Sun P, Jhutty D, Zheng GX, Nemec CM, Dai X, Watanabe K^#, Kessenbrock K^#. Integrated single-cell transcriptomics and chromatin accessibility analysis reveals novel regulators of mammary epithelial cell identity. Cell Reports. 2020 Oct 20; 33(3):108273. LINK

Alshetaiwi H, Pervolarakis N, McIntyre LL, Ma D, Nguyen QH, Rath JA, Nee K, Hernandez G, Evans K, Torosian L, Silva A, Walsh C, Kessenbrock K. Defining the emergence of myeloid-derived suppressor cells in breast cancer using single-cell transcriptomics. Science Immunology. 2020 Feb 21;5(44). pii: eaay6017. doi: 10.1126/sciimmunol.aay6017

Haensel DH, Jin S, Cinco R, Sun P, Nguyen QH, Cang Z, Dragan M, Gong Y, MacLean AL, Kessenbrock K, Gratton E, Nie Q, Dai X. Defining epidermal basal cell states during skin homeostasis and wound healing using single-cell transcriptomics. Cell Reports. 2020 Mar 17;30(11):3932-3947.e6. doi: 10.1016/j.celrep.2020.02.091.

2019

Guerrero-Juarez CF, Dedhia PH, Jin S, Ruiz-Vega R, Ma D, Liu Y, Yamaga K, Shestova O, Gay DL, Yang Z, Kessenbrock K, Nie Q, Pear WS, Cotsarelis G, Plikus MV. Single-cell analysis reveals fibroblast heterogeneity and myeloid-derived adipocyte progenitors in murine skin wounds. Nature Communications. 2019 Feb 8;10(1):650. doi: 10.1038/s41467-018-08247-x.

2018

Lawson DA^#, Kessenbrock K^#, Davis RT, Pervolarakis N, Werb Z. Tumour Heterogeneity and metastasis in single-cell resolution. Nature Cell Biology. 2018 20, 1349-1360. https://www.nature.com/articles/s41556-018-0236-7 ^#corresponding author

Nguyen QH*, Pervolarakis N*, Blake K, Ma D, Davis RT, James J, Phung AT, Willey E, Kumar R, Jabart E, Driver I, Rock J, Goga A, Khan SA, Lawson DA, Werb Z^#, Kessenbrock K^#. Profiling human breast epithelial cells using single cell RNA sequencing reveals spectrum of cell diversity. Nature Communications  2018 May 23;9(1):2028. https://rdcu.be/OZmF ^#corresponding author; *Co-first author

Nguyen QH, Pervolarakis N, Nee K, Kessenbrock K^#. Experimental considerations for single cell RNA sequencing approaches. Front. Cell. Dev. Biol. 2018 Sep 4;6:108. https://doi.org/10.3389/fcell.2018.00108 ^#corresponding author

2017

Kessenbrock K*, Smith P*, Steenbeek S, Pervolarakis N, Kumar R, Minami Y, Goga A, Hinck L, Werb Z. Diverse regulation of mammary epithelial growth and branching morphogenesis through non-canonical Wnt signaling. Proc. Natl. Acad. Sci. 2017. 114(12):3121-3126        *contributed equally

2016

Horiuchi D, Zhou AY, Corella AN, Yau C, Balakrishnan S, Kessenbrock K, Lawson DA, Anderton BN, Bazarov AV, Eyob H, Yaswen P, McManus MT, Rugo HS, Werb Z, Goga A. PIM kinase inhibition presents a novel targeted therapy against triple-negative breast tumors with elevated MYC expression. Nat Med. 2016 Nov;22(11):1321-1329. doi: 10.1038/nm.4213.

Park J, Wysocki RW, Amoozgar Z, Maiorino L, Fein MR, Jorns J, Schott AF, Kinugasa-Katayama Y, Lee Y, Won NH, Nakasone ES, Hearn SA, Küttner V, Qiu J, Almeida AS, Perurena N, Kessenbrock K, Goldberg MS, Egeblad M. Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps. Science Translational Medicine. 2016 Oct 19;8(361):361ra138.

Selected Publications from before Lab Start in 2016

Lawson D.A., Bhakta N., Kessenbrock K., Prummel K., Yu Y., Takai K., Yaswen P., Welm A., Goga A., Werb Z., Single-cell analysis reveals a stem cell transcription program in human metastatic breast cancer cells. Nature. 2015 526:131-5

Kessenbrock K.*, Dijkgraaf G.J.*, Lawson D.A., Littlepage L.E., Shahi P., Pieper U., Werb Z. A role for matrix metalloproteinases in the regulation of mammary stem cells via the Wnt signaling pathway. Cell Stem Cell. 2013; 13:300-13; *equal contribution

Caudrillier A., Kessenbrock K., Gilliss, B.M., Ngyen J.X., Marques M.B., Monestier M., Toy P., Werb Z., Looney M.R., Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury. J Clin Invest. 2012; 122:2661-71.

Kessenbrock K., Plaks V., Werb Z., Matrix Metalloproteinases: Regulators of the Tumor Microenvironment. Cell. 2010; 141:52-67. Review

Kessenbrock K.#, Krumbholz M., Schoenermarck U., Back W., Gross W.L., Werb Z., Groene H.J., Brinkmann V., Jenne D.E. #, Netting neutrophils in autoimmune small-vessel vasculitis. Nat Med. 2009; 15:623-625. #corresponding author

Kessenbrock K.#, Fröhlich L., Sixt M., Lämmermann T., Bateman A., Belaaouaj A., Ring J., Ollerrt M., Fässler R., Jenne D.E. #, Proteinase 3 and neutrophil elastase enhance inflammation by inactivating anti-inflammatory progranulin. J Clin Invest. 2008; 118:2438-2447. #corresponding author

Riedl J.*, Crevenna A.H.*, Kessenbrock K., Yu J.H., Neukirchen D., Bista M., Bradke F., Jenne D.E., Holak T.A., Werb Z., Sixt M., Wedlich-Soldner R., Lifeact – a novel versatile marker for the visualization of F-actin. Nat Meth. 2008; 5:605-607. *equal contribution

Kessenbrock K., Fritzler M.J., Groves M., Eissfeller P., von Mühlen C.A., Höpfl P., Mahler M., Diverse humoral autoimmunity to the ribosomal P proteins in systemic lupus erythematosus and hepatitis C virus infection. J Mol Med. 2007 85:953-959.LINK