The Kessenbrock Lab studies cellular communication in single cell resolution in the context of normal tissue homeostasis and in breast cancer. We want to understand how stem cell behavior is extrinsically regulated by the microenvironment of the mammary stem cell niche and learn how the molecular composition of the niche changes during tumorigenesis. Our interdisciplinary research approach will identify biomarkers for early detection and may ultimately lead to the discovery of novel therapeutic approaches to treat or even prevent breast cancer before it develops.
Kai Kessenbrock, Ph.D.
University of California, Irvine
School of Medicine
Department of Biological Chemistry
Chao Family Comprehensive Cancer Center
Center for Complex Biological Systems
Sue and Bill Gross Stem Cell Research Center
Lab Beach Day – July 2017/in Uncategorized /by Kai
Seminar Speaker Long Cai visiting from Caltech/in Uncategorized /by Kai
The Kessenbrock lab and the Department of Biological Chemistry is hosting Dr. Long Cai from the California Institute of Technology. Dr. Cai shared his exciting findings on “Spatial Genomics: single cell in situ and lineage analysis” on May 17th, 2017, 11:00AM-12:00PM in the Hitachi Lecture Hall. Thanks to Andrew Komoto for helping to organize Long’s visit, and to Quy Nguyen for serving as student host.
Komen Breast Cancer Educational Series hosted at UCI/in Uncategorized /by Kai
Susan G. Komen® Orange County, in partnership with leading Orange County breast centers has created a comprehensive breast health education series to inform and empower breast cancer patients to take charge of your breast health. On Oct 18th, 2016, it was our turn to host this event focusing on “Metastasis Research, Treatment, and Prevention Advances: From Bench to Bedside” at the UCI Chao Family Comprehensive Cancer Center organized by Dr. Devon Lawson with talks by Dr. Ritesh Parajuli and Dr. Kai Kessenbrock. Close to 100 breast cancer patients, survivors and advocates signed up for this event. Thanks to the students in the Kessenbrock and Lawson labs for helping to organize this event.
Presentation at 2nd Annual Single Cell Analysis USA Congress in Boston, USA/in Uncategorized /by Kai
The Annual Single Cell Analysis USA Congress conference focused on the latest developments in single cell analysis research as well as the latest technologies and applications utilised in the single cell industry. Kai presented the labs progress on our single cell analyses on transcriptomic and epigenetic heterogeneity within the human breast epithelial system.
Invited seminar at Tsinghua University in Beijing, China/in Uncategorized /by Kai
Kai was invited to give a talk on “Understanding breast cancer initiation and progression in single cell resolution” hosted by Prof. Jinzhi Lei from the Zhou Pei-Yuan Center for Applied Mathematics at Tsinghua University in Beijing, China.
Tsinghua University (abbreviated THU; Chinese: 清华大学) is a research university located in Beijing, China, and one of the nine members in the elite C9 League of universities. Established in 1911, and with its motto of Self-Discipline and Social Commitment, Tsinghua University describes itself as being dedicated to academic excellence, the well-being of Chinese society and to global development. With strong research and training, Tsinghua University is consistently ranked as one of the top academic institutions in China (says Wikipedia).
Quy Nguyen received CCBS Opportunity Award/in Uncategorized /by Kai
Congratulations to Quy for winning one of this year’s Opportunity Awards from the Center for Complex Biological Systems (CCBS) together with Tao Peng from Qing Nie’s lab at UCI. This award will foster the collaboration between the Nie and Kessenbrock labs on “Understanding the systems-level changes during breast tumorigenesis using single cell RNA-seq”. Each winning proposal will receive $10,000 to be shared between the labs for project expenses; and a $1,000 award for research supplies to be shared between students. The results of this project will be presented at next year’s annual CCBS retreat scheduled for March 31 – April 2nd, 2017, due to be held in Pasadena, CA!
Nick Pervolarakis funded by NIH-T32 Training Grant/in Uncategorized /by Kai
Congratulations to Nick for getting one of the competitive slots on the NIH-T32 Training Grant of the Mathematical, Computational and Systems Biology Program!
Talk at the Stem Cell Niche Conference in Copenhagen/in Uncategorized /by Kai
Kai gave a talk at the “Stem Cell Niche – Development and Disease” Conference organized by the NovoNordisk Foundation. The aim of the conference is to provide a niche for presentations of the latest basic research in stem cell and developmental biology and to stimulate exchange of ideas by providing ample time for both formal and informal discussions.
The conference took place at the beautiful Favrholm campus, which is situated 30 km north of Copenhagen in lush rural surroundings.
Seminar Speaker Roberto Zoncu visiting from UC Berkeley/in Uncategorized /by Kai
The Kessenbrock lab and the Department of Biological Chemistry is hosting Roberto Zoncu from the Department of Molecular and Cell Biology at UC Berkeley. His seminar “The lysosome in nutrient sensing and cellular growth control” takes place on May 18th, 2016, 11:00AM-12:00PM in the Hitachi Lecture Hall. Thanks to Andrew Komoto for helping to organize Robero’s visit, and to Selma Alkafeef for serving as student host.
Lab Opening Party – Cinco de Mayo/in Uncategorized /by Kai
The Lawson and Kessenbrock labs have celebrated their lab openings on Thursday, May 5th 5pm in the court yard between Sprague Hall and Hewitt Hall with drinks and tacos on Cinco de Mayo. Thanks to all lab members in the photo who helped organizing this event – and of course to everyone at UCI who joined us in our fiesta!