University of California, Irvine - Department of Biological Chemistry
Stem Cell Niche
The mammary gland as a versatile model system to study adult stem cell function. Image shows mammary gland reconstituted with GFP-expressing mammary stem cells.
TUMORIGENESIS IN SINGLE CELL RESOLUTION
Keratin-8 and -14 double positive cells emerge during MMP3-induced tumorigenesis. We analyze the early tumorigenic changes of the mammary system in single cell resolution.
INFLAMMATION AND CANCER
Neutrophil granulocytes (yellow) extravasating from blood vessels into inflamed tissue. We study the role of secreted proteases as mediators of inflammation in the tumor microenvironment.
JOIN THE LAB
The lab is located in Sprague Hall, the home of the UCI Cancer Research Institute
We study cellular communication on a systems-level in the context of normal tissue homeostasis and in breast cancer to ultimately improve methods of early detection, cancer treatment and potentially cancer prevention.
Overview of recent featured publications and complete list of research articles. Find out more about our published work here.
JOIN THE LAB
We are looking to hire new talent. If you are passionate about science and innovation, and if you are interested in stem cell and cancer research, find out here how to join the lab.
The Kessenbrock Lab studies cellular communication in single cell resolution in the context of normal tissue homeostasis and in breast cancer. We want to understand how stem cell behavior is extrinsically regulated by the microenvironment of the mammary stem cell niche and learn how the molecular composition of the niche changes during tumorigenesis. Our interdisciplinary research approach will identify biomarkers for early detection and may ultimately lead to the discovery of novel therapeutic approaches to treat or even prevent breast cancer before it develops.
Kai Kessenbrock, Ph.D.
University of California, Irvine
School of Medicine
Department of Biological Chemistry
Chao Family Comprehensive Cancer Center
Center for Complex Biological Systems
Sue and Bill Gross Stem Cell Research Center
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