Featured Pubs



Nguyen QH*, Pervolarakis N*, Blake K, Ma D, Davis RT, James J, Phung AT, Willey E, Kumar R, Jabart E, Driver I, Rock J, Goga A, Khan SA, Lawson DA, Werb Z#, Kessenbrock K#. Profiling human breast epithelial cells using single cell RNA sequencing reveals spectrum of cell diversity. Nature Communications (in press) #corresponding author; *Co-first author

Nguyen QH, Pervolarakis N, Nee K, Kessenbrock K#. Experimental considerations for single cell RNA sequencing approaches. Front. Cell. Dev. Biol. (in press) #corresponding author;

Takai K, Drain AP, Lawson DA, Littlepage LE, Karpuj M, Kessenbrock K, Le A, Inoue K, Weaver VM and Werb Z. Discoidin domain receptor 1 (DDR1) ablation promotes tissue fibrosis and hypoxia to induce aggressive, basal-like breast cancers. Genes & Dev. In press (2018).


Kessenbrock K*, Smith P*, Steenbeek S, Pervolarakis N, Kumar R, Minami Y, Goga A, Hinck L, Werb Z. Diverse regulation of mammary epithelial growth and branching morphogenesis through non-canonical Wnt signaling. Proc. Natl. Acad. Sci. 2017. 114(12):3121-3126        *contributed equally


Horiuchi D, Zhou AY, Corella AN, Yau C, Balakrishnan S, Kessenbrock K, Lawson DA, Anderton BN, Bazarov AV, Eyob H, Yaswen P, McManus MT, Rugo HS, Werb Z, Goga A. PIM kinase inhibition presents a novel targeted therapy against triple-negative breast tumors with elevated MYC expression. Nature Medicine. 2016 Nov;22(11):1321-1329. doi: 10.1038/nm.4213.

Park J, Wysocki RW, Amoozgar Z, Maiorino L, Fein MR, Jorns J, Schott AF, Kinugasa-Katayama Y, Lee Y, Won NH, Nakasone ES, Hearn SA, Küttner V, Qiu J, Almeida AS, Perurena N, Kessenbrock K, Goldberg MS, Egeblad M. Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps. Science Translational Medicine. 2016 Oct 19;8(361):361ra138.


Lawson D.A., Bhakta N., Kessenbrock K., Prummel K., Yu Y., Takai K., Yaswen P., Welm A., Goga A., Werb Z., Single-cell analysis reveals a stem cell transcription program in human metastatic breast cancer cells. Nature. 2015 526:131-5

Kessenbrock K., Wang C.Y., Werb Z. Matrix metalloproteinases in stem cell regulation and cancer. Matrix Biol. 2015. 44:184-190.


Kessenbrock K.*, Dijkgraaf G.J.*, Lawson D.A., Littlepage L.E., Shahi P., Pieper U., Werb Z. A role for matrix metalloproteinases in the regulation of mammary stem cells via the Wnt signaling pathway. Cell Stem Cell. 2013; 13:300-13; *equal contribution
Featured in: “Preview” Cell Stem Cell. 2013; 13:300; “Research Highlights” Nat Cell Biol. 2013; 15:1033.


Caudrillier A., Kessenbrock K., Gilliss, B.M., Ngyen J.X., Marques M.B., Monestier M., Toy P., Werb Z., Looney M.R., Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury. J Clin Invest. 2012; 122:2661-71. (>100 Citations)
Featured in: http://www.nhlbi.nih.gov/news/spotlight/fact-sheet/nhlbi-top-research-findings-in-fiscal-year-2012.html


Kessenbrock K., Brown M., Werb Z., Measuring matrix metalloproteinase activity in macrophages and polymorphonuclear leukocytes. Curr Protoc Immunol. 2011 Chapter 14:Unit14.24. Review


Kessenbrock K., Plaks V., Werb Z., Matrix Metalloproteinases: Regulators of the Tumor Microenvironment. Cell. 2010; 141:52-67. Review (>1,200 Citations)

Kessenbrock K., Dau T., Jenne D.E., Tailor-made inflammation: how neutrophil serine proteases modulate the inflammatory response. J Mol Med. 2010; 89:23-28. (>30 Citations)


Kessenbrock K.#, Krumbholz M., Schoenermarck U., Back W., Gross W.L., Werb Z., Groene H.J., Brinkmann V., Jenne D.E. #, Netting neutrophils in autoimmune small-vessel vasculitis. Nat Med. 2009; 15:623-625. #corresponding author (>350 Citations)
Featured in: “Editor’s Choice” Science. 2009; 324:1242; “Research Highlights” Nat Rev Rheum. 2009; 5:413


Kessenbrock K.#, Fröhlich L., Sixt M., Lämmermann T., Bateman A., Belaaouaj A., Ring J., Ollerrt M., Fässler R., Jenne D.E. #, Proteinase 3 and neutrophil elastase enhance inflammation by inactivating anti-inflammatory progranulin. J Clin Invest. 2008; 118:2438-2447. #corresponding author (>150 Citations)
Featured in: “In this issue” J Clin Invest. 2008; 118:2367; “Research highlights” Nat Rev Immunol. 2008; 8:572

Riedl J.*, Crevenna A.H.*, Kessenbrock K., Yu J.H., Neukirchen D., Bista M., Bradke F., Jenne D.E., Holak T.A., Werb Z., Sixt M., Wedlich-Soldner R., Lifeact – a novel versatile marker for the visualization of F-actin. Nat Meth. 2008; 5:605-607. *equal contribution (>580 Citations)


Kessenbrock K., Fritzler M.J., Groves M., Eissfeller P., von Mühlen C.A., Höpfl P., Mahler M., Diverse humoral autoimmunity to the ribosomal P proteins in systemic lupus erythematosus and hepatitis C virus infection. J Mol Med. 2007 85:953-959.

Kessenbrock K., Raijmakers R., Fritzler M.J., Mahler M., Synthetic peptides: The future of patient management in systemic rheumatic diseases? Curr Med Chem. 2007; 14:2831-2838.


Mahler M., Kessenbrock K., et al. International multicenter evaluation of autoantibodies to ribosomal P proteins. Clin Vaccine Immunol. 2004; 13:77-83.

Mahler M., Kessenbrock K., Raats J., Fritzler M.J., Technical and clinical evaluation of anti-ribosomal P protein immunoassays. J Clin Lab Anal. 2004; 18:215-23.


Mahler M., Kessenbrock K., Raats J., Williams R., Fritzler M.J., Bluthner M., Characterization of the human autoimmune response to the major C-terminal epitope of the ribosomal P proteins. J Mol Med. 2003 81:194-204.

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