The first lab holiday party (joined between Villalta, Lawson, Kessenbrock Labs) took place at our house in Laguna Beach. Due to persistent Santa Ana winds and 84F (~30C) warm weather we switched our theme from Xmas Sweaters and Snow Boots to Hawaiian Flower Leis and Flip Flops – Mele Kalikimaka everyone!
Together with Nick Navin’s lab at MD Anderson and Devon Lawson’s lab at UCI, we have secured pilot funds from the Chan Zuckerberg Initiative to build the first comprehensive cell atlas of the human breast tissue in single cell resolution. This project is based on multimodal analyses of breast tissues that bring together diverse assays, including single cell transcriptomics, spatial genomics, epigenetics, and histology.
Please check out the following links for more information:
Our collaboration with Dr. Eva Lee’s Lab on “Hormonal modulation and genetic alterations in breast carcinogenesis” got funded by the Breast Cancer Research Foundation (BCRF). The BCRF is a nonprofit organization committed to achieving prevention and a cure for breast cancer. We are grateful for their generous support and we are excited to get to work on this important research project exploring the biology of breast cancer formation in BRCA1 mutation carriers.
Congratulations to the winners of this year’s CCBS Opportunity Awards competition based on the theme of Crossing Scales with Cell-Level Data! This collaboration with Ali Mortazavi’s Lab focusing on “Doublet Cell Sequencing to Elucidate Stem Cell Niche in Mouse Epithelium ” will be carried by Dr. Dennis Ma and Nick Pervolarakis (Kessenbrock Lab) and Camden Jansen (Mortazavi Lab). Each winning proposal will receive $10,000 to be shared between the faculty for lab project expenses; and a $1,000 award for research supplies to be shared between student and/or postdoctoral participants. We look forward to hearing about the projects at next year’s annual CCBS retreat scheduled for Spring quarter 2018, due to be held in the Los Angeles area!
The Kessenbrock lab and the Department of Biological Chemistry is hosting Dr. Long Cai from the California Institute of Technology. Dr. Cai shared his exciting findings on “Spatial Genomics: single cell in situ and lineage analysis” on May 17th, 2017, 11:00AM-12:00PM in the Hitachi Lecture Hall. Thanks to Andrew Komoto for helping to organize Long’s visit, and to Quy Nguyen for serving as student host.
Susan G. Komen® Orange County, in partnership with leading Orange County breast centers has created a comprehensive breast health education series to inform and empower breast cancer patients to take charge of your breast health. On Oct 18th, 2016, it was our turn to host this event focusing on “Metastasis Research, Treatment, and Prevention Advances: From Bench to Bedside” at the UCI Chao Family Comprehensive Cancer Center organized by Dr. Devon Lawson with talks by Dr. Ritesh Parajuli and Dr. Kai Kessenbrock. Close to 100 breast cancer patients, survivors and advocates signed up for this event. Thanks to the students in the Kessenbrock and Lawson labs for helping to organize this event.
The Annual Single Cell Analysis USA Congress conference focused on the latest developments in single cell analysis research as well as the latest technologies and applications utilised in the single cell industry. Kai presented the labs progress on our single cell analyses on transcriptomic and epigenetic heterogeneity within the human breast epithelial system.
Kai was invited to give a talk on “Understanding breast cancer initiation and progression in single cell resolution” hosted by Prof. Jinzhi Lei from the Zhou Pei-Yuan Center for Applied Mathematics at Tsinghua University in Beijing, China.
Tsinghua University (abbreviated THU; Chinese: 清华大学) is a research university located in Beijing, China, and one of the nine members in the elite C9 League of universities. Established in 1911, and with its motto of Self-Discipline and Social Commitment, Tsinghua University describes itself as being dedicated to academic excellence, the well-being of Chinese society and to global development. With strong research and training, Tsinghua University is consistently ranked as one of the top academic institutions in China (says Wikipedia).
Congratulations to Quy for winning one of this year’s Opportunity Awards from the Center for Complex Biological Systems (CCBS) together with Tao Peng from Qing Nie’s lab at UCI. This award will foster the collaboration between the Nie and Kessenbrock labs on “Understanding the systems-level changes during breast tumorigenesis using single cell RNA-seq”. Each winning proposal will receive $10,000 to be shared between the labs for project expenses; and a $1,000 award for research supplies to be shared between students. The results of this project will be presented at next year’s annual CCBS retreat scheduled for March 31 – April 2nd, 2017, due to be held in Pasadena, CA!
The Kessenbrock Lab studies cellular communication in single cell resolution in the context of normal tissue homeostasis and in breast cancer. We want to understand how stem cell behavior is extrinsically regulated by the microenvironment of the mammary stem cell niche and learn how the molecular composition of the niche changes during tumorigenesis. Our interdisciplinary research approach will identify biomarkers for early detection and may ultimately lead to the discovery of novel therapeutic approaches to treat or even prevent breast cancer before it develops.
Kai Kessenbrock, Ph.D.
University of California, Irvine
School of Medicine
Department of Biological Chemistry
Chao Family Comprehensive Cancer Center
Center for Complex Biological Systems
Sue and Bill Gross Stem Cell Research Center