Our grant application 1R01CA234496-01 was selected for funding by the National Cancer Institute (NCI). This grant will support the lab from 2019-2024 with annually $353,419 in total funding to elucidate microenvironmental control mechanisms that regulate breast tumorigenesis such as during BRCA1-driven breast cancer. While the microenvironment has been studied extensively in later stages of tumor progression, it remains largely elusive whether changes in the non-malignant stroma can contribute to increased cancer susceptibility and tumor initiation. Ultimately we hope that this work will lead to the development improved methods for breast cancer early detection and novel approaches for primary cancer prevention.